Neuroendocrine neoplasms of the lung: a pathology update
نویسندگان
چکیده
منابع مشابه
Classification and pathology of ic neuroendocrine neoplasms
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are composed of cells with a neuroendocrine phenotype. The old and the new WHO classifications distinguish between well-differentiated and poorly differentiated neoplasms. All well-differentiated neoplasms, regardless of whether they behave benignly or develop metastases, will be called neuroendocrine tumours (NETs), and graded G1 (Ki67...
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15 صفحه اولAn update on the pathology of neuroendocrine tumors.
In this review, we highlight different aspects of a specialized tumor subset, neuroendocrine tumors. We discuss the terminology applied to these tumors, define their precancerous state, diagnostic criteria, immunohistochemical and molecular markers and finally the grading system that is currently applied to these subset of tumors.
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In 1983, Gerdes, Schwab, Lemke and Stein reported upon a new monoclonal antibody which was generated by immunizing mice with nuclei of the Hodgkin lymphoma cell line L428. This antibody was found to label nuclei of proliferating cells including tumor cells. In their report the authors therefore concluded that “Ki-67 (a name derived from the city of Kiel where the authors worked, and the number ...
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ژورنال
عنوان ژورنال: memo - Magazine of European Medical Oncology
سال: 2021
ISSN: 1865-5041,1865-5076
DOI: 10.1007/s12254-021-00681-w